Association of miR-146aC>G, miR-196a2T>C, and miR-499A>G Polymorphisms With R…

We investigated whether microRNA (miRNA) polymorphisms (miR-146aC>G, miR-196a2T>C, and miR-499A>G) confer risk of premature ovarian failure (POF) in Korean women. DNA samples from 136 patients with POF and 234 controls were genotyped for the 3 miRNA single-nucleotide polymorphisms by polymerase chain reaction–restriction fragment length polymorphism. The miR-146aCG/miR-196a2TC combined geno…