e-journal

Parkinson’s Disease and Cancer: A Register-based Family Study

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We wanted to compare cancer incidence rates between Parkinson’s disease (PD) patients and persons without
PD, as well as between siblings of these groups. We conducted a family-based matched cohort study based on
nationwide Swedish health registries and the Swedish Multi-Generation Register.We assessed risk of incident cancer in PD patients (n = 11,786) during 1964–2009 versus a matched cohort of PD-free individuals (n = 58,930) and in siblings of PD patients (n = 16,841) versus siblings of PD-free individuals (n = 84,205). Hazard ratios with 95% confidence intervals were estimated using Cox proportional hazards regression. Cancer occurrence was slightly higher in PD patients than in PD-free individuals (hazard ratio (HR) = 1.05, 95% confidence interval (CI): 1.00, 1.10), largely because of cancers arising within 1 year before or after the index date for PD, but risk of smokingrelated cancers was lower (HR = 0.87, 95% CI: 0.79, 0.96). PD patients had a higher risk of melanoma both up to 1 year before the PD index date (HR = 1.53, 95% CI: 1.23, 1.91) and from 1 year after the index date onward (HR = 1.46, 95% CI: 1.01, 2.10). In the sibling comparison, cancer occurrence was largely similar. These results indicate that melanoma risk is higher among PD patients and that mechanisms other than familial ones explain the association.

cancer; cohort studies; hazard ratio; Parkinson’s disease; siblings

Abbreviations: CI, confidence interval; HR, hazard ratio; ICD-7, International Classification of Diseases, Seventh Revision; L-DOPA, L-3,4-dihydroxyphenylalanine; PD, Parkinson’s disease; SD, standard deviation.

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Informasi Detail

Judul Seri

American Journal of Epidemiology

No. Panggil

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Penerbit

: Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health., 2014

Deskripsi Fisik

Am J Epidemiol. 2014;179(1):85–94

Bahasa

English

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KESEHATAN

Info Detail Spesifik

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Pernyataan Tanggungjawab

agus

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