e-journal
Biochemically Controlled Bioelectrocatalytic Interface
Natural biochemical processes are controlled and regulated by different mechanisms at various levels of complexity involving numerous biochemical and physiological reactions.1 Artificial biocatalytic and particularly bioelectrocatalytic processes used in various bioelectronic devices, such as biosensors, biofuel cells, and bioactuators, are suffering from the lack of the biochemical control and regulation. Recently developed switchable and tunable bioelectrocatalytic systems are controlled by various physical input
signals: electrical,2 magnetic,3 light,4 etc. allowing their applications in novel biosensors5 and biofuel cells6 with an adjustable performance. However, this approach does not provide biochemical/physiological control over their operation. There is an obvious need of another kind of their functional regulation based on an interface between bioelectronic systems and their biochemical environment. The present paper addresses the challenging aim of biochemical control over bioelectronic systems by integrating a bioelectrocatalytic
system with a stimuli-responsive material and enzymecatalyzed stimuli-generating reactions.
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