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Preparation of Supramolecular Graft Copolymers and the Subsequent Formation of pH-Sensitive Vesicles

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A feasible methodology for the preparation of vesicles through self-assembly of supramolecular graft
copolymers (SGPs) was developed. Two types of polymeric vesicles were prepared through self-assembly
of two SGPs. For the first SGP, hydrophobic poly(4-vinylpyridine) (PVPy) were used as main chains,
and hydrophilic poly(N-vinylpyrrolidone) with carboxylic end groups (PNVP-COOH) were grafted onto
the main chains through ionic interaction between the carboxylic groups and pyridine groups. For the
second SGP, hydrophobic poly(4-acrylamidobenzoic acid) (PABA) were used as main chains, and poly(Nvinylpyrrolidone) with amino end groups were grafted onto the main chains through ionic interaction
between the amino groups and carboxylic groups. Both SGPs could self-assemble to form vesicles in
aqueous solution. The size of the vesicles prepared from the PVPy/PNVP-COOH (or PABA/PNVPNH2)
system could be controlled through modulation of the mass ratio of PVPy and PNVP-COOH (or PABA and PNVP-NH2). Both vesicles were sensitive to pH and could be deformed by changing pH. Drug-release studies showed that release rates of the loaded drug (sunset yellow) in the two vesicles could be well-controlled by the pH of the releasing solution.

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Ketersediaan

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Informasi Detail

Judul Seri

Chemistry of Materials

No. Panggil

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Penerbit

Washington, DC : American Chemical Society., 2009

Deskripsi Fisik

Chem. Mater. 2009, 21, 758–762

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

agus

Versi lain/terkait

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