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Synthesis, characterization and release of curcumin-intercalated Mg–Al-layered double hydroxides

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Abstract.
A drug-inorganic clay composite involving a pharmaceutically active compound curcumin (Cur) intercalated Mg–Al layered double hydroxides (Cur-LDHs) with Mg/Al=3 has been assembled by co-precipitation and ion-exchange methods. Powder X-ray diffraction (XRD) and Fourier transform infrared spectra (FT-IR) analysis indicate a successful intercalation of Cur between the layers with monolayer horizontal (parallel to the layer) and vertical (perpendicular to the layer) orientations of Cur anion. (TGDTA) analyses shows that the thermal stability of intercalated organic species is largely enhanced due to host–guest interaction involving the hydrogen bond compared to pure form before intercalation. The release studies show that release percentages
decrease with increasing pH from 4.0 to 6.5 due to possible change of release mechanism during the release process. The kinetic simulation for the release data indicates that the dissolution mechanism is mainly responsible for the release behavior of Cur-LDHs at pH 4.0, while the ion-exchange one is responsible for that at pH 6.5. It suggests that layered double hydroxides may have application as the basis of a novel tunable drug delivery system.

Keywords: Layered double hydroxides; Curcumin; Drug-inorganic composite; Intercalation; Release

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Informasi Detail

Judul Seri

Applied Clay Science

No. Panggil

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Penerbit

London : Elsevier B.V.., 2008

Deskripsi Fisik

Applied Clay Science 40 (2008) 72–80

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

agus

Versi lain/terkait

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