e-journal

Design and optimization of a new self-nanoemulsifying drug delivery system

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Abstract.
To improve the dissolution rate of ibuprofen, a model poorly water soluble drug, self-nanoemulsifying
drug delivery systems (SNEDDS) were developed. Various surfactants and oils were screened as
candidates for SNEDDS on the basis of droplet size of the resulting emulsions. The influence of the
constituent structure, concentration and the composition of SNEDDS formulations, and the emulsifier
HLB value, on the properties of the resulting emulsions was systematically investigated. Several SNEDDS
formulations were employed to study the relationship between the emulsion droplet size and the
dissolution rate of ibuprofen. The dissolution rate was accelerated by decreasing the nanoemulsion
droplet size, and was significantly faster than that from a conventional tablet. The optimal SNEDDS
formulation had a mean nanoemulsion droplet diameters of 58 nm in phosphate buffer, pH 6.8 (simulated
intestinal fluid), and released ibuprofen more than 95% within 30 min. Therefore, these novel SNEDDS
carriers appear to be useful for controlling the release rate of poorly water soluble drugs.

Keywords: Droplet size, Self-nanoemulsifying drug delivery systems, (SNEDDS), Ibuprofen, Dissolution rate

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Informasi Detail

Judul Seri

Journal of Colloid and Interface Science

No. Panggil

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Penerbit

London : Elsevier Inc.., 2009

Deskripsi Fisik

Journal of Colloid and Interface Science 330 (2009) 443–448

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

agus

Versi lain/terkait

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