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Preparation and characterization of thermo-responsive PDMS surfaces grafted with poly(N-isopropylacrylamide) by benzophenone-initiated photopolymerization

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Abstract.
In the preparation of a thermo-responsive, poly(N-isopropylacrylamide) (PNIPAAm)-grafted polydimethylsiloxane
(PDMS) surface by means of benzophenone-initiated photopolymerization, we observed that
thick (>1 mm) PDMS substrates were much more difficult to be grafted with PNIPAAm than thin ones.
Investigations revealed that the shortage of diffused benzophenone molecules in the surface region
of the thick substrate might be the reason. By prolonging the time spent for treating the substrate
with a benzophenone solution, PNIPAAm could be successfully grafted onto thick PDMS substrates. The
PNIPAAm-grafted PDMS surface was highly thermo-responsive. The contact angle on a grafted surface
increased from 38 to 91◦ in response to the temperature increase from 20 to 38 ◦C. An electroosmotic
flow (EOF) mobility of 5 × 10−4 cm2/Vs was supported by a PNIPAAm-grafted PDMS channel at 50 ◦C,
whereas negligible EOF was observed at 20 ◦C. Doxorubicin (DX), an anticancer drug, was adsorbed by
the grafted surface at 40◦C, and the majority of the adsorbed DX was quickly released from the surface
to a stripping solution at 5 ◦C. Osteoblast cells adhered onto the PNIPAAm-grafted PDMS surface and
proliferated therein at 37 ◦C, while the cell sheet detached from the surface by lowering the temperature
to 25 ◦C without using any enzymatic agent.

Keywords:
Polydimethylsiloxane
Poly(N-isopropylacrylamide)
Thermal-responsive surface
Drug release
Cell culture
Microfluidic chip

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Informasi Detail

Judul Seri

Journal of Colloid and Interface Science

No. Panggil

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Penerbit

London : Elsevier Inc.., 2009

Deskripsi Fisik

Journal of Colloid and Interface Science 332 (2009) 85–90

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

agus

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