e-journal

Preparation of honeycomb scaffold with hierarchical porous structures by core-crosslinked core–corona nanoparticles

---

Abstract.
The preparation of honeycomb scaffold with hierarchical controllable porous structures is reported. The
ABA three block amphiphilic copolymer PS-b-P(St-Alt-AMn)-b-PS was synthesized through reversible
addition fragmentation chain transfer polymerization (RAFT) and subsequently self-assembled to core–
corona nanoparticles with the middle block P(St-Alt-AMn) as the core and two side block PS as the
corona. The formed core–corona nanoparticles were further crosslinked through the reaction of amino
diphenyl methane with anhydride in chains. The core-crosslinked core–corona nanoparticles were used
as the building block to fabricate the controllable porous scaffold with hierarchical structure. The
micrometer level honeycomb mesostructures can be obtained by an inverse emulsion template method
which is consisted in the formation of the high internal phase ratio emulsions (HIPRE) while the
nanometer level pores are formed by the close-packed core–corona block copolymer nanoparticles. As
carboxylic group is formed in the crosslink step of the core, the growth factor can be easily incorporated
into the matrix in order for the growth of the cell in the tissue engineering application. This kind
of hierarchical honeycomb structure is an ideal candidate for the tissue engineering and drug delivery
applications.

Keywords:
Emulsion template
Honeycomb scaffold
Core–corona nanoparticles
Amphiphilic block copolymer

---

Ketersediaan

Tidak ada salinan data

Informasi Detail

Judul Seri

Journal of Colloid and Interface Science

No. Panggil

-

Penerbit

London : Elsevier Inc.., 2009

Deskripsi Fisik

Journal of Colloid and Interface Science 332 (2009) 165–172

Bahasa

English

ISBN/ISSN

-

Klasifikasi

-

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

-

Subjek

KIMIA

Info Detail Spesifik

-

Pernyataan Tanggungjawab

agus

Versi lain/terkait

Lampiran Berkas

Komentar

---

Anda harus masuk sebelum memberikan komentar