Effects of surface wettability and roughness of microchannel on flow behaviors of thermo-responsive microspheres therein during the phase transition

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Effects of surface wettability and roughness of microchannel on flow behaviors of thermo-responsive microspheres therein during the phase transition

Ming-Yu Zhou - Nama Orang; Bin Liang - Nama Orang; Gang Chen - Nama Orang; Rui Xie - Nama Orang; Ya-Lan Yu - Nama Orang; Xiao-Jie Ju - Nama Orang; Lihua Yang - Nama Orang; Liang-Yin Chu - Nama Orang;

Abstract.
The flow characteristics of monodisperse thermo-responsive poly(N-isopropylacrylamide) (PNIPAM)
microspheres during the phase transition in microchannels with different surface wettabilities and
roughnesses are investigated systematically. Glass microchannels are modified by hydroxylation treatment
to achieve hydrophilic surface, by self-assembly of chlorotrimethylsilane to realize hydrophobic
surface, and by coating with silica nanoparticles to generate rough surface. The phase transition of PNIPAM
microspheres in microchannels is induced by local heating. The results show that the surface wettability
and roughness of microchannel significantly affect the flow behaviors of PNIPAM microspheres
during the phase transition. It is much easier for the PNIPAM microspheres in microchannel with hydrophobic
surface to stop right after the phase transition than those in microchannel with hydrophilic surface,
and it is also much easier for the PNIPAM microspheres in microchannel with rough surface to stop
right after the phase transition than those in microchannel with smooth surface. These results indicate
that hydrophobic and rough surface properties of the microchannel can enhance the site-specific targeting
of PNIPAM microspheres caused by the phase transition. The results in this study provide valuable
information for the application of thermo-responsive drug carriers in site-specific targeting therapy.

Keywords:
Thermo-responsive microspheres
Flow characteristics
Phase transition
Surface wettability
Surface roughness

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Informasi Detail

Judul Seri: Journal of Colloid and Interface Science
No. Panggil: -
Penerbit: London : Elsevier Inc.., 2009
Deskripsi Fisik: Journal of Colloid and Interface Science 336 (2009) 162–170
Bahasa: English
ISBN/ISSN: -
Klasifikasi: -
Tipe Isi: -
Tipe Media: -
Tipe Pembawa: -
Edisi: -
Subjek: KIMIA
Info Detail Spesifik: -
Pernyataan Tanggungjawab: agus

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Effects of surface wettability and roughness of microchannel on flow behaviors of thermo-responsive microspheres therein during the phase transition

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