e-journal

Targeted removal of bioavailable metal as a detoxification strategy for carbon nanotubes

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Abstract.
There is substantial evidence for toxicity and/or carcinogenicity upon inhalation of pure
transition metals in fine particulate form. Carbon nanotube catalyst residues may trigger
similar metal-mediated toxicity, but only if the metal is bioavailable and not fully encapsulated
within fluid-protective carbon shells. Recent studies have documented the presence
of bioavailable iron and nickel in a variety of commercial as-produced and vendor ‘‘purified’’
nanotubes, and the present article examines techniques to avoid or remove this bioavailable
metal. First, data are presented on the mechanisms potentially responsible for
free metal in ‘‘purified’’ samples, including kinetic limitations during metal dissolution,
the re-deposition or adsorption of metal on nanotube outer surfaces, and carbon shell
damage during last-step oxidation or one-pot purification. Optimized acid treatment protocols
are presented for targeting the free metal, considering the effects of acid strength,
composition, time, and conditions for post-treatment water washing. Finally, after optimized
acid treatment, it is shown that the remaining, non-bioavailable (encapsulated)
metal persists in a stable and biologically unavailable form up to two months in an
in vitro biopersistence assay, suggesting that simple removal of bioavailable (free) metal
is a promising strategy for reducing nanotube health risks.

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Ketersediaan

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Informasi Detail

Judul Seri

C A R B ON

No. Panggil

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Penerbit

London : Elsevier Ltd.., 2008

Deskripsi Fisik

C A R B ON 4 6 ( 2 0 0 8 ) 4 8 9 –5 0 0

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

agus

Versi lain/terkait

Lampiran Berkas

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