e-journal

Invasive Haemophilus influenzae Disease in Adults ≥65 Years, United States, 2011

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Background.
Since the introduction of the Haemophilus influenzae serotype b vaccine, H influenzae epidemiology
has shifted. In the United States, the largest burden of disease is now in adults aged ≥65 years. However, few data exist on risk factors for disease severity and outcome in this age group.

Methods.
A retrospective case-series review of invasive H influenzae infections in patients aged ≥65 years was
conducted for hospitalized cases reported to Active Bacterial Core surveillance in 2011.

Results.
There were 299 hospitalized cases included in the analysis. The majority of cases were caused by nontypeable
H influenzae, and the overall case fatality ratio (CFR) was 19.5%. Three or more underlying conditions were
present in 63% of cases; 94% of cases had at least 1. Patients with chronic heart conditions (congestive heart failure, coronary artery disease, and/or atrial fibrillation) (odds ratio [OR], 3.27; 95% confidence interval [CI], 1.65–6.46), patients from private residences (OR, 8.75; 95% CI, 2.13–35.95), and patients who were not resuscitate status (OR, 2.72; 95% CI, 1.31–5.66) were more likely to be admitted to the intensive care unit (ICU). Intensive care unit admission (OR, 3.75; 95% CI, 1.71–8.22) and do not resuscitate status (OR, 12.94; 95% CI, 4.84–34.55) were significantly associated with death.

Conclusions.
Within this age group, burden of disease and CFR both increased significantly as age increased. Using ICU admission as a proxy for disease severity, our findings suggest several conditions increased risk of disease
severity and patients with severe disease were more likely to die. Further research is needed to determine the most effective approach to prevent H influenzae disease and mortality in older adults.

Keywords. Haemophilus influenzae; older adults.

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Informasi Detail

Judul Seri

Open Forum Infectious Diseases

No. Panggil

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Penerbit

Oxford : Oxford University Press on behalf of the Infectious Diseases Society of America., 2014

Deskripsi Fisik

Open Forum Infectious Diseases, Volume 1 Issue 2 Summer 2014

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KESEHATAN

Info Detail Spesifik

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Pernyataan Tanggungjawab

agus

Versi lain/terkait

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