e-book

The Physics of Coronary Blood Flow

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Coronary blood flow is blood flow to the heart for its own metabolic needs.
In the most common form of heart disease there is a disruption in this flow
because of obstructive disease in the vessels that carry the flow. The subject of
coronary blood flow is therefore associated mostly with the pathophysiology
of this disease, rarely with dynamics or physics. Yet, the system responsible
for coronary blood flow, namely the “coronary circulation,” is a highly sophisticated
dynamical system in which the dynamics and physics of the flow are
as important as the integrity of the conducting vessels. While an obstruction
in the conducting vessels is a fairly obvious and clearly visible cause of disruption
in coronary blood flow, any discord in the complex dynamics of the
system can cause an equally grave, though less conspicuous, disruption in the
flow.

This book is devoted specifically to the dynamics and physics of coronary
blood flow. While it upholds the clinical and pathophysiological issues
involved, the book focuses on dynamics and physics, approaching the subject
from a strictly biomedical engineering viewpoint. The rationale for this
approach is simply that the coronary circulation involves many issues in dynamics
and physics, as the book will demonstrate. Also, with this particular
focus, the book will complement other books on the subject, that have so far
focused largely on clinical and pathophysiological issues.

A study of the dynamics of the coronary circulation requires far more
information about the system than is currently available. Whether in terms
of anatomical details of the vasculature, system properties such as capacitance
and elasticity of the conducting vessels, or the basic and regulatory conditions
under which the system operates, the information currently available is highly
incomplete. Thus, the scope of this book is limited to dynamical aspects of
coronary blood flow, but within these limits it is also constrained to deal
necessarily with an incomplete picture of these dynamics. In particular, the
book does not include the microcirculation, the venous part of the coronary
circulation, Thebesian veins or the lymphatic system. Also, the many-faceted
regulatory mechanisms of the coronary circulation are not considered in any
systematic or factual way, but only tangentially in how they may affect the
dynamics of the system. These omissions reflect the degree of complexity of
the coronary circulation and serve as a sober reminder that it may never be
possible or practical to deal with this complexity in a single book.

What seems possible at this time is to use known elements or properties
of the system in such a way as to construct a meaningful, though incomplete,
model of the system. This is the spirit in which the content of this book
is presented. The book deals essentially with the dynamics of that part of
the coronary circulation extending from the coronary ostia at the base of
the aorta to the capillary level of coronary vasculature. It is meaningful to
consider this part of the system in isolation because this is where the largest
part of the pressure drop driving the flow occurs. While the dynamics of this
part of the system may not represent the dynamics of the system as a whole,
they demonstrate clearly the role of dynamics in the coronary circulation
and illustrate how a disruption in these dynamics can affect coronary blood
flow as significantly as can the obstruction of a blood vessel. This is indeed
what the present book is about. Other books have in the past focused in
a similar way on clinical or pathophysiological aspects of the system, or on
the microcirculation. Each of these must clearly be seen as representing an
important, though equally incomplete, view of the system.

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Ketersediaan

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Informasi Detail

Judul Seri

BIOLOGICAL AND MEDICAL PHYSICS BIOMEDICAL ENGINEERING

No. Panggil

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Penerbit

New York : Springer Science+Business Media, Inc.., 2005

Deskripsi Fisik

(MP) 9 8 7 6 5 4 3 2 1. xvii, 408 hlm.

Bahasa

English

ISBN/ISSN

0387260196

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

BIOLOGICAL AND MEDICAL PHYSICS BIOMEDICAL ENGINEER

Subjek

FISIKA KEDOKTERAN

Info Detail Spesifik

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Pernyataan Tanggungjawab

agus

Versi lain/terkait

Lampiran Berkas

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