e-book

Guide for The Care and Use of Laboratory Animals

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This eighth edition of the Guide is divided into five chapters and four
appendices.
Chapter 1 presents the goals and intended audiences of the
Guide as well as key concepts and terminology essential to its premise
and use. Incorporating some of the material from the Introduction to the
last edition, the chapter highlights a commitment to the concepts of the
Three Rs—Replacement, Reduction, and Refinement—and provides an
enhanced discussion of the ethics of animal use and investigator/institutional
obligations.

Chapter 2 focuses on the overall institutional animal care and use
program (Program), in addition to many of the topics previously covered in
Chapter 1 of the seventh edition. It defines the evolved concept of Program
and provides a framework for its intra-institutional integration, taking into
account institutional policies and responsibilities, regulatory considerations,
Program and personnel management (including training and occupational
health and safety), and Program oversight. Discussions of the latter include
institutional animal care and use committee (IACUC) functions, protocol
and Program review, postapproval monitoring (a new section), and considerations
such as humane endpoints and multiple survival surgical procedures.
The Committee endorses the American College of Laboratory Animal
Medicine’s “Guidelines for Adequate Veterinary Care.”

Chapter 3 focuses on the animals themselves and, unlike previous editions,
addresses terrestrial and aquatic species in separate sections, reflectxvii
ing the growing role of aquatic animals in biomedical research. The chapter
provides recommendations for housing and environment, discusses the
importance of social housing, and includes enhanced sections on environmental
enrichment, animal well-being, and scientific validity.

Space recommendations were nominally expanded based on the Committee’s
professional and expert opinion and on current housing methods.
Cage sizes have historically been interpreted as minimum space needs by
users of the Guide, and were labeled as such (“recommended minimum
space”) in this edition. The use of the word “minimum” does not further
restrict users of the Guide because, although the space requirements are
numbers (i.e., engineering standards), they are used in a performance standards
framework. The Committee recommends minimum space for female
rodents with litter and an increase of the cage height for rabbits to 16”.
Further, in light of many comments submitted to the Committee requesting
more information on performance goals and how to achieve them, rodent
breeding recommendations are accompanied by substantial guidance.
With respect to nonhuman primates (NHPs), the Committee endorses
social housing as the default and has provided some species-specific guidance.
An additional group has been added for monkeys, and chimpanzees
are separated in a new category. These changes were motivated by the
Committee’s recognition (affirmed in comments solicited from NHP experts)
that these animals need more floor and vertical space, at least in some
groups, to exercise their natural habits.

Chapter 4 discusses veterinary care and the responsibilities of the
attending veterinarian. It introduces the concept of animal biosecurity and
upholds its central role in ensuring the health of laboratory animals. The
chapter includes recommendations relative to animal procurement, transportation,
and preventive medicine, and expands the sections on clinical
care and management, surgery (with a new section on intraoperative monitoring),
pain and distress, and euthanasia.

Chapter 5 discusses physical plant–related topics and includes updated
and new material on vibration control; physical security and access control;
hazardous agent containment; and special facilities for imaging and
whole body irradiation, barrier housing, behavioral studies, and aquatic species
housing. The chapter provides detailed discussion of centralized versus
decentralized animal facilities and introduces the concept of variable-volume
HVAC systems with a nod toward energy conservation and efficiency.

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Ketersediaan

Tidak ada salinan data

Informasi Detail

Judul Seri

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No. Panggil

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Penerbit

Washington, D.C. : The National Academy of Sciences of the USA., 2011

Deskripsi Fisik

xix, 220 hlm.

Bahasa

English

ISBN/ISSN

978-0-309-15401-7

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

Eighth Edition

Subjek

ZOOLOGY

Info Detail Spesifik

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Pernyataan Tanggungjawab

agus

Versi lain/terkait

Lampiran Berkas

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