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Molecular biology of the cell [PART 4. INTERNAL ORGANIZATION OF THE CELL]

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In many respects, we understand the structure of the universe better than the
workings of living cells. Scientists can calculate the age of the Sun and predict
when it will cease to shine, but we cannot explain how it is that a human being
may live for eighty years but a mouse for only two. We know the complete
genomes equences of these and many other species, but we still cannot predict
how a cell will behave if we mutate a previously unstudied gene. Stars may be
l043 times bigger, but cells are more complex, more intricately structured, and
more astonishing products of the laws of physics and chemistry. Through heredity
and natural selection, operating from the beginnings of life on Earth to the
present day-that is, for about 20% of the age of the universe-living cells have
been progressively refining and extending their molecular machinery and
recording the results of their experiments in the genetic instructions they pass
on to their progeny.

With each edition of this book, we marvel at the new information that cell
biologists have gathered in just a few years. But we are even more amazed and
daunted at the sophistication of the mechanisms that we encounter. The deeper
we probe into the cell, the more we realize how much remains to be understood.
In the days of our innocence, working on the first edition, we hailed the identification
of a single protein-a signal receptol say-as a great step forward' Now
we appreciate that each protein is generally part of a complex with many others,
working together as a system, regulating one another's activities in subtle ways,
and held in specific positions by binding to scaffold proteins that give the chemical
factory a definite spatial structure. Genome sequencing has given us virtually
complete molecular parts-lists for many different organisms; genetics and
biochemistry have told us a great deal about what those parts are capable of
individually and which ones interact with which others; but we have only the
most primitive grasp of the dynamics of these biochemical systems, with all
their interlocking control loops. Therefore, although there are great achievements
to report, cell biologist sf ace even greater challenges for the future.

In this edition, we have included new material on many topics, ranging from
epigenetics, histone modifications, small RNAs,and comparative genomics, to
genetic noise, cytoskeletal dynamics,cell-cyclec ontrol, apoptosis,stem cells,
and novel cancer therapies. As in previous editions, we have tried above all to
give readers a conceptual framework for the mass of information that we now
have about cells. This means going beyond the recitation of facts. The goal is to
learn how to put the facts to use-to reason, to predict, and to control the
behavior of living systems.

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Ketersediaan

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Informasi Detail

Judul Seri

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No. Panggil

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Penerbit

London : Garland Science Taylor & Francis Group., 2008

Deskripsi Fisik

QH581.2.M 64 ; 571.6--dc22

Bahasa

English

ISBN/ISSN

978-0-815-4106-2

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

5th ed.

Subjek

BIOLOGI SEL

Info Detail Spesifik

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Pernyataan Tanggungjawab

agus

Versi lain/terkait

Lampiran Berkas

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