e-journal

Osteogenesis of mineralized collagen bone graft modified by PLA and calcium sulfate hemihydrate: In vivo study

---

In this study, the biocompatibility and bone regeneration performance of nano-hydroxyapatite/collagen/poly(L-lactide)(nHAC/PLA) and nano-hydroxyapatite/collagen/calcium sulfate hemihydrate (nHAC/CSH) as bone-filling materials were evaluated and compared in a critical box-shaped defect model in the mandible of the rabbits. In vivo results indicated that there was significant difference in early bone remodeling between two types of bone substitutes. nHAC/PLA has shown excellent iocompatibility, but no adequate handling properties. The addition of CSH to nHAC provided better manipulability
compared to nHAC/PLA. Furthermore, nHAC/CSH possesses superior properties in restoring critical-sized
bone defects of maxillofacial region at the early stage of remodeling over nHAC/PLA. Our results suggested that nHAC/CSH could be an alternative to the conventionally used bone tissue engineering materials.

Keywords Bone repair materials, nano-hydroxyapatite/collagen, calcium sulfate, osteogenesis, PLA

---

Ketersediaan

Tidak ada salinan data

Informasi Detail

Judul Seri

Journal of Biomaterials Applications

No. Panggil

-

Penerbit

: SAGE Publications Ltd., 2012

Deskripsi Fisik

Journal of Biomaterials Applications 28(1) 12–19 , 2012

Bahasa

English

ISBN/ISSN

-

Klasifikasi

-

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

-

Subjek

BIOKIMIA

Info Detail Spesifik

-

Pernyataan Tanggungjawab

hasnidar/agus

Versi lain/terkait

Lampiran Berkas

Komentar

---

Anda harus masuk sebelum memberikan komentar