e-journal

A new accurate, simple formula for LDL-cholesterol estimation based on directly measured blood lipids from a large cohort

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Background: Low-density lipoprotein cholesterol (LDL-c) is the major measured parameter for cardiovascular risk assessment. The generally accepted formula (LDL-F) for estimating LDL-c developed by Friedewald and colleagues in 1972 using data from 448 individuals suffers from known inaccuracies at extremes of triglyceride (TG) and total cholesterol (TC) values. Methods: We generated new formulas based on a large Brazilian database containing directly measured lipid values from 10,664 fasted individuals. This database LDL-c was measured by the LDL-C Select FS (DiaSys) system, a homogeneous
method without centrifugation. The formulas were generated using linear and non-linear approaches, and the formula with
the highest accuracy and simplicity for general clinical use was selected.
Results: The simple formula LDL-c ¼ 3/4 (TC2 HDL-c) provided an accurate estimate of LDL-c, a higher correlation with
directly measured LDL (r ¼ 0.93) compared with LDL-F (r ¼ 0.87), and also a higher accuracy.
Conclusions: The new formula outperformed several other LDL-c formulas over a wide range of TC, HDL-c and TG values. The validation and application of this formula in other populations is warranted.

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Informasi Detail

Judul Seri

Annals of Clinical Biochemistry

No. Panggil

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Penerbit

: SAGE Publications Ltd., 2013

Deskripsi Fisik

Annals of Clinical Biochemistry 2013; 50: 13–19

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

BIOKIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

hasnidar/agus

Versi lain/terkait

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