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Vitamin A supplementation, serum lipids, liver enzymes and C-reactive protein concentrations in obese women of reproductive age

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Background: High-dose vitamin A influences glucose and lipid profile; however, the possible effects of moderate doses (25,000 IU/d) are conflicting. We aimed to compare the effect of vitamin A pplementation on several anthropometric and biochemical variables between obese and non-obese women.
Methods: This study was performed on 84 women among whom 56 were obese (body mass index [BMI] 30–35 kg/m2) and 28 were non-obese (BMI 18.5–24.9 kg/m2). Obese women were randomly divided into two groups: one group received 25,000 IU/d retinyl palmitate and another group received placebo. The third group was age-matched non-obese women who received 25,000 IU/d retinyl palmitate. At baseline and four months after intervention, fasting blood glucose (FBG),lipid profile, C-reactive protein (CRP) and liver enzymes were evaluated. Results: Baseline concentrations of serum FBG and triglyceride in the obese vitamin A-treated group were significantly higher compared with the other groups (P ¼ 0.004 and 0.007, respectively). A significant increase in serum FBG (P ¼ 0.026), total cholesterol (TC) (P ¼ 0.004) and low-density lipoprotein cholesterol (LDL-C) (P ¼ 0.016) in the non-obese group and a significant decrease in serum high-density lipoprotein cholesterol (HDL-C) (P ¼ 0.001) in the obese group was observed. Serum CRP increased significantly in the obese vitamin A-treated group (P ¼ 0.03) and serum aspartate transaminase increased significantly in the obese and non-obese groups after vitamin A supplementation (P ¼ 0.008 and 0.001, respectively). Conclusions: Treatment with 25,000 IU/d vitamin A induced a mild elevation in serum lipids, CRP and liver enzymes in obese and non-obese women. Considering the other information about possible side-effects of excess vitamin A, use of vitamin A in this dose and duration should be considered with caution.

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Informasi Detail

Judul Seri

Annals of Clinical Biochemistry

No. Panggil

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Penerbit

: SAGE Publications Ltd., 2013

Deskripsi Fisik

Annals of Clinical Biochemistry 2013; 50: 25–30

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

BIOKIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

hasnidar/agus

Versi lain/terkait

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