Identification of a rare variant haemoglobin (Hb Sinai-Baltimore)causing spuriously low haemoglobin A1c values on ion exchange chromatography

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Identification of a rare variant haemoglobin (Hb Sinai-Baltimore)causing spuriously low haemoglobin A1c values on ion exchange chromatography

Geoff Smith - Nama Orang; Heather Murray - Nama Orang; Stephen O Brennan - Nama Orang;

Commonly used methods for assay of haemoglobin A1c (HbA1c) are susceptible to interference from the presence of haemoglobin variants. In many systems, the common variants can be identified but scientists and pathologists must remain vigilant for more subtle variants that may result in spuriously high or low HbA1c values. It is clearly important to recognize these events whether HbA1c is being used as a monitoring tool or, as is increasingly the case, for diagnostic purposes. We report a patient with a rare haemoglobin variant (Hb Sinai-Baltimore) that resulted in spuriously low
values of HbA1c when assayed using ion exchange chromatography, and the steps taken to elucidate the nature of the variant.

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Judul Seri: Annals of Clinical Biochemistry
No. Panggil: -
Penerbit: : SAGE Publications Ltd., 2013
Deskripsi Fisik: Annals of Clinical Biochemistry 2013; 50: 83–86
Bahasa: English
ISBN/ISSN: -
Klasifikasi: -
Tipe Isi: -
Tipe Media: -
Tipe Pembawa: -
Edisi: -
Subjek: BIOKIMIA
Info Detail Spesifik: -
Pernyataan Tanggungjawab: hasnidar/agus

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Identification of a rare variant haemoglobin (Hb Sinai-Baltimore)causing spuriously low haemoglobin A1c values on ion exchange chromatography

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