e-journal

Dynamic Expression Pattern of Neuro-oncological Ventral Antigen 1 (Nova1) in the Rat Brain after Focal Cerebral Ischemia/ Reperfusion Insults

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The present study aimed to evaluate the expression of neuro-oncological ventral antigen 1 (Nova1) in cerebral ischemia/
reperfusion (I/R) insults by immunohistochemistry. The focal cerebral I/R model was induced by right middle cerebral
artery occlusion (MCAO) for 120 min followed by 1 day, 7 days, and 14 days of reperfusion in Sprague-Dawley (SD) rats.
The results showed that Nova1 was expressed in nearly the whole brain, although with higher density in hippocampus,
hypothalamus, cingulate cortex, and medial habenular nucleus. The immunoreactivity of Nova1 neurons was increased
dramatically, especially on both sides of the hippocampal CA1 region, after 1 day of reperfusion. A strong response occurred at the ipsilateral CA1 region between 1 day and 7 days of reperfusion. Likewise, strong compensatory responses of Nova1 expression were observed on the contralateral side of the striate cortex, dentate gyrus, and hypothalamus. Interestingly,
more Nova1 neurons were observed to translocate to the dendrites and growth cones of the axons in the hypothalamus
on the ischemic side after 7 days of reperfusion. In conclusion, our data suggest that Nova1 might mediate neuronal
responsiveness, and its expression might positively correlate with neural repair after I/R insults in the rat brain. (J Histochem
Cytochem 61:45–54, 2013)
Keywords
ischemia/reperfusion insults, middle cerebral artery occlusion, neuron splicing factor Nova1, nuclear-cytoplasmic-neuritic
translocation

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Informasi Detail

Judul Seri

Journal of Histochemistry & Cytochemistry

No. Panggil

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Penerbit

: SAGE Publications Ltd., 2013

Deskripsi Fisik

Journal of Histochemistry & Cytochemistry 61(1) 45– 54 , 2013

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

BIOKIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

hasnidar/agus

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