e-journal

Upregulation of Vascular Endothelial Growth Factor Receptor-3 in the Spinal Cord of Lewis Rats with Experimental Autoimmune Encephalomyelitis

---

We investigated the spatiotemporal expression of vascular endothelial growth factor receptor–3 (VEGFR-3) in the spinal
cord of Lewis rats with experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. VEGFR-3
mRNA and protein were constitutively expressed in gray matter neurons and in a few white matter astrocytes. Induction
of VEGFR-3 occurred predominantly in perivascular infiltrated macrophages in the spinal cord white matter during the
inductive phase of EAE. VEGFR-3 expression was also induced in activated microglial cells in the gray and white matter,
mainly in the peak phase. In addition, reactive astrocytes in the white matter, but not in the gray matter, expressed VEGFR-3 as disease severity increased. These data suggest that VEGFR-3 is involved in the recruitment of monocytic macrophages and in glial reactions during EAE. (J Histochem Cytochem 61:31–44, 2013)

Keywords VEGFR-3, macrophage, microglia, reactive astrocyte, experimental autoimmune encephalomyelitis

---

Ketersediaan

Tidak ada salinan data

Informasi Detail

Judul Seri

Journal of Histochemistry & Cytochemistry

No. Panggil

-

Penerbit

: SAGE Publications Ltd., 2013

Deskripsi Fisik

Journal of Histochemistry & Cytochemistry 61(1) 31– 44 , 2013

Bahasa

English

ISBN/ISSN

-

Klasifikasi

-

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

-

Subjek

BIOKIMIA

Info Detail Spesifik

-

Pernyataan Tanggungjawab

hasnidar/agus

Versi lain/terkait

Lampiran Berkas

Komentar

---

Anda harus masuk sebelum memberikan komentar