e-journal

Dedifferentiated Liposarcoma With Lipoma-Like Well-Differentiated Liposarcoma: Clinicopathological Study of 30 Cases, With Particular Attention to the Comingling Pattern of Well- and Dedifferentiated Components: A Proposal for Regrouping of the Present Subclassification of Well-Differentiated Liposarcoma and Dedifferentiated Liposarcoma

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Dedifferentiated liposarcoma (DDL) is defined as nonlipogenic sarcoma, with an abrupt transition from coexisting
well-differentiated liposarcoma (WDL). However, intermingled transition in a mosaic pattern between WDL and DDL
is not infrequently encountered. Here, the authors review clinicopathological features of 30 cases of DDL associated
with lipoma-like WDL. Histological examination revealed 20 tumors that showed an abrupt transition between
WDL and DDL. Among these, 13 tumors showed high-grade spindle-cell sarcoma having histological features of
unclassified malignant fibrous histiocytoma (MFH)-like sarcoma (high-grade DDL [HDDL]). The remaining 7 tumors
showed moderate cellular spindle-cell proliferation with mild nuclear atypia and scant mitotic figures (low-grade DDL
[LDDL]). The other 10 tumors showed intermingled transition between WDL and DDL. The interface between these
2 components overlapped, resulting in frequent occurrence of a lipogenic spindle-cell component (comingling DDL).
Based on the cellularity and nuclear atypia of the spindle-cell components, there were 7 comingling HDDLs and 3
comingling LDDLs. The histology of comingling LDDL simulated an admixture of spindle-cell liposarcoma and LDDL,
and distinction from each other was practically difficult. The histology of comingling HDDL simulated pleomorphic
liposarcoma. Follow-up data, available for 23 patients (median, 39 months), showed that 2 patients died of tumor
(both had HDDL), and 1 patient died of unrelated disease; 8 patients were alive with recurrent or metastatic diseases (3 HDDLs, 3 LDDLs, and 2 comingling HDDLs). Statistical analysis by Fisher’s exact test showed no correlation between
histological subtypes (HDDL and LDDL, and typical DDL and comingling DDL).

Keywords well-differentiated liposarcoma, dedifferentiated liposarcoma, low-grade dedifferentiation, lipogenic spindle-cell component, spindle-cell liposarcoma

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Informasi Detail

Judul Seri

International Journal of Surgical Pathology

No. Panggil

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Penerbit

: SAGE Publications Ltd., 2013

Deskripsi Fisik

International Journal of Surgical Pathology 21(1) 15– 21 , 2013

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

FARMASI

Info Detail Spesifik

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Pernyataan Tanggungjawab

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