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Ameliorating effects of curcumin and vitamin E on diazinon-induced oxidative damage in rat liver and erythrocytes

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The aim of this study was to evaluate the protective effects of vitamin E and/or curcumin against diazinon
(DZN) (an organophosphorus insecticide)-induced toxicity of blood, liver and erythrocyte markers of male
Wistar rats. The exposure of rats to DZN for 21 days provoked significant changes in red blood cell counts and
hemoglobin. Results showed that lipid peroxidation increased significantly in DZN-treated rats, as evidenced
by high liver and erythrocyte thiobarbituric acid reactive substance levels. Alteration of the antioxidant system in
DZN-treated rats was confirmed by the significant decrease in the activity of catalase, glutathione peroxidase and
glutathione-S-transferase, accompanied by a decline in reduced glutathione content in both tissues.On the other
hand, a significant increase in the activities of plasma aspartate transaminase, alanine transaminase, lactate dehydrogenase and alkaline phosphatase was observed in the rats treated with DZN. However, the administration of
vitamin E and curcumin has ameliorated the previous markers. In conclusion, our results indicate that the natural
antioxidants like vitamin E and curcumin can effectively lower the erythrocytes and hepatic injuries induced by
DZN as monitored by lipid peroxides, antioxidant enzyme activities and sensitive serum enzyme levels.

Keywords Biochemical markers, curcumin, diazinon, oxidative stress, protective effects, rat, vitamin E

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Informasi Detail

Judul Seri

Toxicology and Industrial Health

No. Panggil

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Penerbit

: SAGE Publications Ltd., 2012

Deskripsi Fisik

Toxicology and Industrial Health 29(1) 77–88 , 2012

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KESEHATAN
FARMASI

Info Detail Spesifik

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Pernyataan Tanggungjawab

hasnidar

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