e-journal

Impaired Endothelial-Dependent and Endothelium-Independent Vasodilatation in Patients With Thromboangiitis Obliterans

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Endothelial dysfunction is the key process in the development of atherosclerosis. The aim of our study was to
evaluate endothelial dysfunction measured by the noninvasive technique of Celermajer that plays a role in the pathogenesis of thrombangitis obliterans. Methods: A total of 36 patients with thrombangitiis obliterans ([TAO]; mean age 44.9+1.3 years) were compared with 30 healthy individuals (mean age 36.1 + 1.8 years). High frequency ultrasound was used to measure changes in response to reactive hyperemia (leading to flow-mediated endothelium-dependent dilatation) and in response to 0.4 mg sublingual nitroglycerin ([NTG]; leading to NTG-induced, endothelium-independent dilatation). Results: Patients with TAO showed a lower but statistically not significant flow-mediated dilatation and a statistically significant reduced NTG-induced vasodilatation than the control group. Conclusion: Our results suggest that both mechanisms play a role in patients with TAO, the endotheliumindependent impaired vasodilatation even in a more significant way than the impaired endothelium-dependent vasodilatation.

Keywords endothelial dysfunction, thrombangitis obliterans, flow-mediated-endothelial dependent dilatation, nitroglycerin, nitroglycerininduced endothelium independent vasodilatation

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Informasi Detail

Judul Seri

Clinical and Applied Thrombosis/Hemostasis

No. Panggil

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Penerbit

: SAGE Publications Ltd., 2013

Deskripsi Fisik

Clinical and Applied Thrombosis/Hemostasis 19(1) 33-36 , 2013

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

FARMASI

Info Detail Spesifik

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Pernyataan Tanggungjawab

hasnidar/agus

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