e-journal

A Novel Polymorphism of the CYP4A11 Gene is Associated With Coronary Artery Disease

---

CYP4A11 (cytochrome P450, family 4, subfamily A, polypeptide 11) converts arachidonic acid to 20- ydroxyeicosatetraenoic acid (20-HETE), which plays a crucial role in the modulation of cardiovascular homeostasis. The aim of the present study was to assess the association between the human CYP4A11 gene and coronary artery disease (CAD). Methods: A total of 361 patients with CAD and 315 controls were genotyped for 4 single-nucleotide polymorphisms (SNPs) of the human CYP4A11 gene (rs9332978, rs4660980, rs3890011, and rs1126742). The data were assessed for 3 groups: total participants, men, and women via case–control studies. Results: For total participants and men, the distribution of SNP3 (rs3890011) genotypes showed a significant difference between CAD and control participants (P ¼ .030 and P ¼ .013, respectively), the distribution of the recessive model of SNP3 (GG vs CC þ GC) was significantly higher in CAD patients than in control participants (P ¼ .011 and P ¼ .014, respectively), the significant difference was retained after adjustment for covariates (for total participants, 95% confidence interval [CI]: 1.137-2.423, P ¼ .009; and for males, 95% CI: 1.173-3.013, P ¼ .009). Conclusions: rs3890011 maybe a novel polymorphism of the CYP4A11 gene associated with CAD in a Han Chinese population.

Keywords CYP4A11, single-nucleotide polymorphism, case–control study

---

Ketersediaan

Tidak ada salinan data

Informasi Detail

Judul Seri

Clinical and Applied Thrombosis/Hemostasis

No. Panggil

-

Penerbit

: SAGE Publications Ltd., 2013

Deskripsi Fisik

Clinical and Applied Thrombosis/Hemostasis 19(1) 60-65 , 2013

Bahasa

English

ISBN/ISSN

-

Klasifikasi

-

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

-

Subjek

KESEHATAN
FARMASI

Info Detail Spesifik

-

Pernyataan Tanggungjawab

hasnidar/Agus

Versi lain/terkait

Lampiran Berkas

Komentar

---

Anda harus masuk sebelum memberikan komentar