e-journal

Elevated Circulating Levels of Tissue Factor in Polycystic Ovary Syndrome

---

Women with polycystic ovary syndrome (PCOS) have coagulation disturbances and inflammation, which increases the risk of
atherothrombosis. We evaluated the status of circulating tissue factor (TF), the receptor for coagulation factor VII involved in atherothrombosis, in women with PCOS and weight-matched controls. Two-way analysis of variance models were fit to evaluate the effect of PCOS status and weight class on TF and other parameters. The TF levels were significantly higher in lean women with PCOS compared to lean controls. Plasminogen activator inhibitor 1 (PAI-1) levels were significantly higher in obese participants compared to lean participants after controlling for PCOS status. The TF levels directly correlated with percentage of truncal fat and plasma levels of PAI-1, testosterone, androstendione, and dehydroepiandrosterone-sulfate; and inversely correlated with insulin sensitivity index–OGTT(ISOGTT). Circulating TF is elevated in PCOS independent of obesity, but both PCOS and obesity contribute to a prothrombotic state. In PCOS, abdominal adiposity and hyperandrogenism may exacerbate the risk of atherothrombosis.
Keywords hyperandrogenism, blood coagulation factors, atherosclerosis, thrombosis

---

Ketersediaan

Tidak ada salinan data

Informasi Detail

Judul Seri

Clinical and Applied Thrombosis/Hemostasis

No. Panggil

-

Penerbit

: SAGE Publications Ltd., 2013

Deskripsi Fisik

Clinical and Applied Thrombosis/Hemostasis 19(1) 66-72, 2013

Bahasa

English

ISBN/ISSN

-

Klasifikasi

-

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

-

Subjek

FARMASI

Info Detail Spesifik

-

Pernyataan Tanggungjawab

hasnidar/Agus

Versi lain/terkait

Lampiran Berkas

Komentar

---

Anda harus masuk sebelum memberikan komentar