e-journal

A Common Susceptibility Factor of Both Autism and Epilepsy: Functional Deficiency of GABAA Receptors

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Abstract
Autism and epilepsy are common childhood neurological disorders with a great heterogeneity of clinical
phenotypes as well as risk factors. There is a high co-morbidity of autism and epilepsy. The neuropathology of autism and epilepsy has similar histology implicating the processes of neurogenesis, neural migration, programmed cell death, and neurite outgrowth. Genetic advances have identified multiple molecules that participate in neural development, brain network connectivity, and synaptic
function which are involved in the pathogenesis of autism and epilepsy. Mutations in GABAA receptor subunit have been frequently associated with epilepsy, autism, and other neuropsychiatric disorders. In this paper, we address the hypothesis that functional deficiency of GABAergic signaling is a potential common molecular mechanism underpinning the co-morbidity of autism and epilepsy.

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Ketersediaan

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Informasi Detail

Judul Seri

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No. Panggil

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Penerbit

: Springer US., 2013

Deskripsi Fisik

J Autism Dev Disord (2013) 43:68–79 DOI 10.1007/s10803-012-1543-7

Bahasa

English

ISBN/ISSN

1573-3432

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KESEHATAN MASYARAKAT
AUTIS

Info Detail Spesifik

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Pernyataan Tanggungjawab

ETY

Versi lain/terkait

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