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Advanced Practical Medicinal Chemistry: Theory-Methodology-Purification-Usages

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The ‘art and skill’ for the preparation of ‘newer drug molecules’ is a pivotal creative and an
exceptionally great intellectual exercise that essentially serves as a fulcrum to plethora of specific
areas of scientific research, ranging from the most applied to the most academic. Accordingly,
the medicinal chemist, organic chemist, biologist, pharmacologist, biochemist,
biotechnologist, phytochemist, genetic engineer, materials scientist, and polymer scientist, in
an university or an industry, all must have genuinely encountered with the most challenging
and intricate task of performing a reaction ultimately leading to an entirely new organic preparation
exhibiting certain specific actions on the biological system to combat diseases in the
ailing human beings.

Invariably, the wonderful ‘magic’ of modern organic synthesis, based on host of documented
theories, hypothesis, organic name reactions (ONRs) amalgamated with logistic, scientific
and assertive reaction mechanism(s), in fact, genuinely paved the way of complicated, notso-
easy, cumbersome course of reactions much simpler and understandable.

The advent of ever-more sophisticated and many supportive modern analytical techniques,
such as : UV, IR, NMR, MS, ORD, CD, AAS, FES, GC, HPLC and the hyphenated
techniques as well, have tremendously enhanced the confidence of medicinal chemists to such a
magnitude as to maximize both the chances of success rate and probability factor.
Besides, the use of organic and inorganic chemicals employed as reactants, catalysts,
medium of reaction, purifying substances etc., are not only harmful but also hazardous in nature.
Nevertheless, the various conditionalities of critical and specific reactions are sometimes
articulated and spelled out so meticulously that one has to follow them just like ‘gospel truth’,
to accomplish the right synthesis, and hence, the right product.

It is, however, pertinent to mention here that the UG and PG students, associated with
the myth and reality of ‘drug synthesis’ should make an honest attempt to carry out a particular
synthesis of a drug substance with a most tried and tested methodical, scientific and rational
approach, so that one may get reproducible results under a particular reaction in a seamless manner.

The copious volumes of textbooks, scientific research journals, monographs, review articles
on related topics like : organic chemistry of drug synthesis, chiral chemistry, drug design,
principles of medicinal chemistry, organic medicinal and pharmaceutical chemistry, and medicinal
chemistry provide ample evidence and scope to suggest that the comprehensive in-depth
knowledge together with utmost specialized state-of-the-art know-how of the various techniques
is an absolute necessity and basic requirement to have a real understanding with regard to the
practical aspects of ‘Medicinal Chemistry’.

In ‘Advanced Practical Medicinal Chemistry’, an attempt has been made to stress
the much needed requirement of both undergraduate and graduate students specializing in the
field of Pharmaceutical Chemistry to learn how to synthesize ‘drugs’ in the laboratory. Unfortunately,
the common available textbooks ordinarily referred to by the Pharmacy Students
mostly deal with the synthesis of pure ‘organic compounds’ ; and hence, do not provide the
real and much needed subject matter relevant to a budding ‘Medicinal Chemist’.

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Ketersediaan

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Informasi Detail

Judul Seri

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No. Panggil

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Penerbit

New Delhi : New Age International (P) Ltd., Publishers., 2004

Deskripsi Fisik

xi, 317 Hlm,

Bahasa

English

ISBN/ISSN

978-81-224-2553-6

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

FARMASI

Info Detail Spesifik

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Pernyataan Tanggungjawab

agus

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