e-book
Essentials of Medical Pharmacology
The unprecedented pace of developments over the recent years in the field of drugs (medicines) has
further emphasized the relevance of Pharmacology to health professionals. Molecular targets of drug
action are being defined at greater resolution, refining new drugs design. Practice of medicine is
transforming from ‘experience (impression) based’ to ‘evidence based’, since more and more credible
evidence from well designed clinical studies is now available on the impact of different treatments
on mortality, morbidity and other therapeutic outcomes. The present edition is oriented to reflect
the contemporary advancements.
Adopting the ‘prototype drug’ approach and a structured, systematic and user-friendly format,
the actions, mechanisms, kinetics and toxicological aspects of drugs are described along with the
pharmacological basis of their use and role/status in the therapy of various diseases/conditions.
By a unique synthesis of pharmacology with clinical medicine, the book is designed to be useful
both to the uninitiated medical student, as well as to prescribing physicians.
All chapters have been updated to include recently introduced drugs and published information.
Latest therapeutic guidelines from leading professional bodies, WHO and National Health
Programmes have been incorporated, especially in areas like hypertension, hyperlipidaemias, stroke
prevention, surgical prophylaxis, tuberculosis, leprosy, malaria, and HIV-AIDS. Recent developments
have been highlighted, notably in hormone replacement therapy, aromatase inhibitors,
bisphosphonates, selective COX-2 inhibitors, atypical antipsychotics, therapy of diabetes mellitus,
heart failure, acute coronary syndromes, Alzheimer’s disease, parkinsonism, glaucoma, kala azar,
etc. A chapter is devoted to the principles of ‘rational use of medicines’, elements of ‘evidence based
medicine’ and the process of ‘new drug development’ to reflect current importance of these topics.
Another new chapter compiles the clinically important drug interactions. Some other topics added
are drug transporters, pharmacogenomics, pharmacovigilance, expiry date of pharmaceuticals, single
enantiomer drugs, biological response modifiers, prescribing in pregnancy, etc.
New drugs marketed in India till mid 2007 are included, while obsolete ones are deleted.
Infrequently used drugs and those not available in India are described briefly in extract type.
Important points are summarized in boxes. Leading trade names with dosage forms are given.
Emphasis is placed on the profile of diseases and drug use in India and other tropical countries,
so as to be particularly useful to students and doctors in these regions; a need not well addressed
by many texts.
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