e-journal

Animal models for percutaneous absorption

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Animalmodels are important tools to predict human in vivo percutaneous absorption/penetration. Monkey, pig, rat, rabbit,guinea pig, hairless rodents, such as hairless rat, hairless mouse, hairless guinea pig and hairless dog, are among the most used animals for this purpose. Each animal model has its own advantages and weakness or limitation. To better correlate animal data with human skin absorption, we need to be familiar with each animalmodel’s characteristics as well as experimental method and condition.We reviewed the original papers published after 1993 that described permeability of both animal skin and human skin. It showed that monkey, pig and hairless guinea pig aremore predictive of human skin absorption/penetration and common laboratory animals, such as rat, rabbit, guinea pig, generally overestimate human skin absorption/penetration.

Keywords: percutaneous absorption/penetration; human; monkey, pig; rat; rabbit; guinea pig; hairless rat; hairless guinea pig

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Informasi Detail

Judul Seri

J. Appl. Toxicol.

No. Panggil

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Penerbit

: John Wiley & Sons., 2015

Deskripsi Fisik

J. Appl. Toxicol. 2015; 35: 1–10

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

FISIKA

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

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