e-journal

Developmental paediatric anaesthetic pharmacology

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Abstract
Safe and effective drug therapy in neonates, infants and children require detailed knowledge about the ontogeny of drug disposition and action as well how these interact with genetics and co-morbidity of children. Recent advances in developmental pharmacology in children follow the increased understanding of the impact of growth and development on drug disposition (ADME: absorption, distribution, metabolism and excretion).Numerous approaches have been used to determine optimal dosing of drugs in children, none of which are perfect. Human growth is a nonlinear process and age-related changes in body composition and organ function are dynamic and often discordant during infancy. Major gaps of
knowledge remain regarding the ontogeny of drug metabolizing enzymes and transporting proteins, and the paucity of pharmacodynamic and pharmacogenetic data in the paediatric population remains overwhelming.

Keywords Drug metabolizing enzymes; ontogeny; paediatric pharmacology; pharmacodynamics; pharmacogenetics; pharmacokinetics

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Ketersediaan

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Informasi Detail

Judul Seri

ANAESTHESIA AND INTENSIVE CARE MEDICINE Volume 16:8 Agustus 2015

No. Panggil

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Penerbit

: Elsevier Ltd., 2015

Deskripsi Fisik

ANAESTHESIA AND INTENSIVE CARE MEDICINE Volume 16:8 Agustus 2015

Bahasa

English

ISBN/ISSN

1472–0299

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

ANASTESI

Info Detail Spesifik

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Pernyataan Tanggungjawab

ETY

Versi lain/terkait

Lampiran Berkas

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