e-journal

The effect of diesel exhaust exposure on blood–brain barrier integrity and function in a murine model

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Epidemiological studies indicate that exposure to diesel exhaust (DE) is associated with vascular-based disorders.
To investigate the effect of DE on blood–brain barrier (BBB) function and integrity, 8-week-old BALB/c mice were randomized to DE in a cyclical treatment regimen over a 2-week period. Functional integrity of BBB was determined by considering brain parenchymal abundance of IgG within the hippocampal formation and cortex at 6 h and 24 h intervals following final exposure treatment. Neurovascular inflammation was expressed as the abundance of glial fibrillar acidic protein. Two doses of DE were studied and compared to air-only treated mice. Mice exposed to DE had substantially greater abundance of parenchymal IgG compared to control mice not exposed to DE. Increased parenchymal glial fibrillar acidic protein at 24 h post-DE exposure suggested heightened neurovascular inflammation. Our findings are proof-of-concept that inhalation of DE can compromise BBB function and support the broader contention that DE exposure may contribute to neurovascular disease risk.

Keywords: Diesel exhaust; Diesel exhaust particle; Blood-brain barrier; Neuroinflammation

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Informasi Detail

Judul Seri

J. Appl. Toxicol.

No. Panggil

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Penerbit

: John Wiley & Sons., 2015

Deskripsi Fisik

J. Appl. Toxicol. 2015; 35: 41–47

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

FISIKA

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

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