Inotropes | Elibrary Perpustakaan Universitas Riau

Pencarian berdasarkan :

SEMUA Pengarang Subjek ISBN/ISSN Pencarian Spesifik

Pencarian terakhir:

e-journal

Inotropes

David J Mayhew - Nama Orang; Kenneth Palmer - Nama Orang;

Abstract
Inotropes are a heterogenous group of drugs that modify calcium handling and alter the force of myocardial contraction. Catecholamines, and their synthetic analogues, increase intracellular calcium by activating cyclic adenosine monophosphate (cAMP) or inositol triphosphate (IP3). Phosphodiesterase inhibitors block phosphodiesterase 3, which in turn reduces catabolism of cyclic nucleotides cAMP and cyclic guanosine monophos phate (cGMP), again increasing intracellular calcium. Cardiac glycosides inhibit the Na þ/Kþ exchanger, and subsequent electrochemical reversal of the Na þ /Ca2þ exchanger causes Ca2þ to rise. Rising intracellular calcium increases inotropy, but risks cardiac arrhythmia, workeperfusion mismatching and myocardial contraction band necrosis. It also risks peripheral ischaemia as intense vasoconstriction is seen with many agents. These effects can be limited by combining low doses of a number of agents, and by understanding the underlying pathology. Novel agents, such as omecamtiv, have multiple beneficial actions, but do not raise intracellular calcium. Their use may become more widespread if clinical data support their efficacy. Inotropes are most often delivered as a central intravenous infusion, commenced and monitored on the intensive care unit with invasive
blood pressure and cardiac output monitoring available.

Keywords Cardiac output; dopamine; enoximone; epinephrine; inotropy; isoproterenol; lusiotropy; milrinone; norepinephrine

Ketersediaan

Tidak ada salinan data

Informasi Detail

Judul Seri: ANAESTHESIA AND INTENSIVE CARE MEDICINE Volume 16:10 Oktober 2015
No. Panggil: -
Penerbit: : Elsevier Ltd., 2015
Deskripsi Fisik: ANAESTHESIA AND INTENSIVE CARE MEDICINE Volume 16:10 Oktober 2015
Bahasa: English
ISBN/ISSN: 1472–0299
Klasifikasi: -
Tipe Isi: -
Tipe Media: -
Tipe Pembawa: -
Edisi: -
Subjek: ANASTESI
Info Detail Spesifik: -
Pernyataan Tanggungjawab: ETY

Versi lain/terkait

Tidak tersedia versi lain

Lampiran Berkas

Inotropes

Komentar

Anda harus masuk sebelum memberikan komentar