e-journal

Effects of cylindrospermopsin on a common carp leucocyte cell line

---

Cylindrospermopsin (CYN) is a cytotoxin produced by different cyanobacterial species, increasingly detected in
water reservoirs worldwide. There is very little information available concerning the effects of the toxin on fish immune cells.The aim of the study was to elucidate the potential impact of cylindrospermopsin on the selected parameters of a common carp (Cyprinus carpio L.) leucocyte cell line (CLC). The cells were incubated with the cyanotoxin at concentrations of 10, 1 or 0.1 μgml–1 for up to 48 h. Cell viability and proliferation, apoptosis/necrosis induction, cell morphology and phagocytic activity were determined. The two higher toxin concentrations occurred to be evidently cytotoxic in a time-dependent manner and influenced all studied parameters. The lowest used concentration had no effects on cell viability and cell number; however, a strong reduction of bacteria uptake after 24-h exposure was detected. The obtained results indicate that cylindrospermopsin may interfere with the basic functions of fish phagocytic cells and as a consequence influence the fish immunity

Keywords: cyanotoxins; cylindrospermopsin; carp leucocyte cell line (CLC); cell viability; apoptosis; necrosis; proliferation; phagocytosis

---

Ketersediaan

Tidak ada salinan data

Informasi Detail

Judul Seri

J. Appl. Toxicol.

No. Panggil

-

Penerbit

: John Wiley & Sons, Ltd.., 2015

Deskripsi Fisik

J. Appl. Toxicol. 2015; 35: 83–89

Bahasa

English

ISBN/ISSN

-

Klasifikasi

-

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

-

Subjek

FISIKA

Info Detail Spesifik

-

Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

Lampiran Berkas

Komentar

---

Anda harus masuk sebelum memberikan komentar