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Medical Biochemistry
A textbook is a snapshot of a field as it exists at the time of writing. Such ‘photographic’ metaphor is appropriate here, because biochemistry undergoes constant change; in the period since the publication of the 3rd edition it has probably changed faster than ever before.
While core metabolic pathways remain largely unchanged, our understanding of underlying regulatory mechanisms is better, thanks to the progress in identifying signaling pathways. In many instances, these pathways have become targets for drugs, and underpin the impressive therapeutic progress in fields such as oncology. Since completion of the Human Genome Project, genomewide association studies and bioinformatic analyses have allowed us to put together a new picture of genetic regulation, the hallmarks of which are interactions between multiple, heterogeneous transcription factors and gene promoters, and the emerging field of epigenetics.
Behind this are, as had happened many times before in the history of science, major advances in methodology, including rapidly expanding genetic screening. The common denominator between methodologies now employed in genetic research laboratories and hospital clinical labs has been the advent of robotics and bioinformatics, and therefore the ability to process – and interpret – an ever-increasing amount of data.
This edition has again been substantially updated. We have rewritten the chapters on lipids, glucose homeostasis, nutrition and biochemical endocrinology, and added a section on the effects of exercise on muscle development and cardiovascular health. The chapter on the -omics incorporates new directions in proteomics, metabolomics and recombinant DNA technology.
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