e-book

Molecular biology of the gene

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THE NEW EDITION OF MOLECULAR BIOLOGY OF THE GENE appears in this, its 7th edition, on
the 60th anniversary of the discovery of the structure of DNA in 1953, an occasion
celebrated by our cover design. The double-helical structure, held together by specific
pairing between the bases on the two strands, has become one of the iconic images
of science. The image of the microscope was perhaps the icon of science in the late
19th century, displaced by the mid 20th century by the graphical representation of the
atom with its orbiting electrons. But by the end of the century that image had in turn given
way to the double helix.

The field of molecular biology as we understand it today was born out of the discovery
of theDNAstructure and the agenda for research that that structure immediately provided.
The paper byWatson and Crick proposing the double helix ended with a nowfamous sentence:
“It has not escaped our notice that the specific pairingwe have postulated immediately
suggests a possible copying mechanism for the genetic material.” The structure
suggested how DNA could replicate, opening the way to investigate, in molecular terms,
how genes are passed down through generations. It was also immediately apparent that
the order of bases along aDNAmolecule could represent a “genetic code,” and so an attack
on that second great mystery of genetics—how genes encode characteristics—could also
be launched.

By the time the first edition of Molecular Biology of the Gene was published, just 12
years later in 1965, it had been confirmed that DNA replicated in the manner suggested
by the model, the genetic code had all but been cracked, and the mechanism by which
genes are expressed, and how that expression is regulated, had been established at least
in outline. The field of molecular biology was ripe for its first textbook, defining for the
first time the curriculum for undergraduate courses in this topic.

Our understanding of the mechanisms underlying these processes has hugely
increased over the last 48 years since that first edition, often driven by technological
advances, including DNA sequencing (another anniversary this year is the 10th anniversary
of completion of the human genome project). The current edition of Molecular Biology
of the Gene celebrates both the central intellectual framework of the field put in place
in that first edition and the extraordinary mechanistic, biological, and evolutionary
understanding that has since been achieved.

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Informasi Detail

Judul Seri

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No. Panggil

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Penerbit

New York : Pearson Education, Inc.., 2014

Deskripsi Fisik

QH506.M6627 - 572’.33--dc23

Bahasa

English

ISBN/ISSN

978-0-321-76243-6

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

BIOLOGI MOLEKULER

Info Detail Spesifik

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Pernyataan Tanggungjawab

agus

Versi lain/terkait

Lampiran Berkas

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