e-journal

Far-Red/Near-Infrared Conjugated Polymer Nanoparticles for Long-Term In Situ Monitoring of Liver Tumor Growth

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The design and synthesis is reported for a fl uorescent conjugated polymer (CP), poly{[4,4,9,9-tetrakis(4-(octyloxy)phenyl-4,9-dihydro- s -indaceno[1,2-b:5,6-b′]dithiophene)]- alt - co -[4,7-di(thiophen-2-yl)-2,1,3-benzothiadiazole]}(PIDT-DBT), with absorption and emission profi les fallen within far-red/near infrared (FR/NIR) region and further demonstrate its application in long-term in vitro cell tracing and in vivo imaging of liver tumor growth. PIDT-DBTTat nanoparticles (NPs) have an absorption maximum at ≈600 nm with an emission maximum at ≈720 nm in water. In vitro cell tracing studies reveal that PIDT-DBT-Tat NPs can trace HepG2 liver cancer cells over 8 d. In vivo
imaging results indicate that PIDT-DBT-Tat NPs can monitor liver tumor growth for more than 27 d in a real-time manner. Both in vitro and in vivo studies demonstrate that PIDT-DBT-Tat NPs are superior to commercial Qtracker 705 as fl uorescent probes. This study demonstrates for the fi rst time the feasibility for long-term in vivo imaging of tumor growth by utilizing CP-based fl uorescent probes, which will encourage the development of NIR fl uorescent CPs for in vivo bioimaging.

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Ketersediaan

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Informasi Detail

Judul Seri

Adv. Sci.

No. Panggil

-

Penerbit

: The Authors., 2015

Deskripsi Fisik

Adv. Sci. 2015, 2, 1500008

Bahasa

English

ISBN/ISSN

DOI: 10.1002

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

-

Edisi

2015, 2

Subjek

KESEHATAN

Info Detail Spesifik

-

Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

Lampiran Berkas

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