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A Discussion of Biological Safety Cabinet Decontamination Methods: Formaldehyde, Chlorine Dioxide, and Vapor Phase Hydrogen Peroxide
This article discusses the three primary methods utilized for the decontamination of Class II biological
safety cabinets (BSCs). Primary methods for BSC decontamination are formaldehyde gas, vapor phase hydrogen
peroxide, and chlorine dioxide gas. Formaldehyde is inexpensive and easy to use; however, it is a possible carcinogen and leaves residues. Both vapor phase hydrogen peroxide and chlorine dioxide gas have the benefit of leaving no residues, but each is an oxidant which may affect materials. The costs for vapor phase hydrogen peroxide are high due to the required equipment; the costs for chlorine dioxide gas can range from low to high depending upon the equipment selected. The cost for formaldehyde is recognized by all as inexpensive in consumables and equipment.
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