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Peptidoglycan from Staphylococcus aureus has an antiapoptotic effect in HaCaT keratinocytes mediated by the production of the cellular inhibitor of apoptosis protein-2

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Colonization of epithelium by microorganisms leads to inflammatory responses. In some cases an anti-apoptotic response involving the cellular inhibitor of apoptosis protein-2 (cIAP-2) also occurs.Although strong expression of cIAP-2 has been observed in lesional skin from psoriatic patients and in HaCaT keratinocytes treated with peptidoglycan (PGN) from Staphylococcus aureus, antiapoptotic responses induced in the skin by cIAP-2 have seldom been studied. In this study, the effect of PGN on TNF-a-induced apoptotic HaCaT keratinocytes was assessed. Morphological analysis,quantification of cells with DNA fragmentation and active caspase-3 detection was performed to assess apoptotic cell death. Greater LL-37 and cIAP-2 production was found in keratinocytes stimulated with PGN than in non-treated cells (P

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Ketersediaan

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Informasi Detail

Judul Seri

Microbiol Immunol

No. Panggil

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Penerbit

: The Societies and Wiley Publishing Asia., 2014

Deskripsi Fisik

Microbiol Immunol 2014; 58: 87–95 doi: 10.1111/1348-0421.12126

Bahasa

English

ISBN/ISSN

doi: 10.1111/1348-04

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

2014; 58

Subjek

KESEHATAN

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

Lampiran Berkas

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