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The kinetics of urinary shedding of BK virus in children with renal disease

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Children with renal diseases are typically treated with immunosuppressive drugs, which place them at
high risk of reactivation of the BK virus (BKV). Currently, little is known about the impact of
immunosuppressive drugs on the kinetics of urinary shedding of BKV and viral reactivation in
pediatric patients with renal diseases. Urine samples were collected monthly for 1 year from 20
children (median age, 9 years; range, 4–15 years) with renal diseases and subjected to real-time PCR.
Urinary shedding of BKV was detected in 35% (7/20) of the patients, three of these patients having
persistent viral DNA excretion (two cases, twelve times; one case, four times) and four having
intermittent viral DNA excretion. Thirty-four of the 240 urine samples contained BKV DNA (median
copy numbers, 5.66 log copies/mL; range, 2.45–7.69 log copies/mL). In two of the cases with persistent
viral shedding, high copy numbers (range, 4.57–7.69 log copies/mL) of BKV DNA were detected in all
12 urine samples collected. In the other case with persistent viral excretion, a range of 2.45–3.98 log
copies/mL of BKV DNA was detected in the four urine samples collected between the 9th and 12th
sampling time points. Additionally, high copy numbers (range, 3.12–4.36 log copies/mL) of BKV
DNA were detected intermittently in the urine samples of the other four cases. No remarkable
correlations were found between the kinetics of BKV DNA loads and urinary findings such as
proteinuria and hematuria. The present data demonstrate the kinetics of urinary BKV shedding in
pediatric patients with renal diseases. Additionally, no pathogenic role for BKV infection was
identified.

Key words BKV, copy number, pediatric, renal disease, real-time polymerase chain reaction.

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Ketersediaan

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Informasi Detail

Judul Seri

Microbiol Immunol

No. Panggil

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Penerbit

: The Societies and Wiley Publishing Asia., 2015

Deskripsi Fisik

Microbiol Immunol 2015; 59: 37–42 12212

Bahasa

English

ISBN/ISSN

doi: 10.1111/1348-04

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KESEHATAN

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

Lampiran Berkas

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