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Outbreak of acute respiratory disease caused by human adenovirus type 7 in a military training camp in Shaanxi, China

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Outbreaks of ARD associated with HAdV have been reported in military populations in many
countries. Here, we report an ARD outbreak caused by HAdV‐7 in a military training camp in Shaanxi
Province, China, from February to March of 2012. Epidemic data and samples from the patients were
collected, and viral nucleotides from samples and viral isolations were detected and sequenced. IgG and
IgA antibodies against HAdV, and the neutralization antibodies against the viral strain isolated in this
outbreak, were detected. Epidemiological study showed that all personnel affected were males with an
average age of 19.1 years. Two peaks appeared on the epicurve and there was an 8‐day interval between
peaks. Laboratory results of viral nucleotide detection carried out with clinical specimens were positive
for HAdV (83.33%, 15/18). Further study through serum antibody assay, virus isolation and
phylogenetic analysis showed that HAdV‐7 was the etiological agent responsible for the outbreak. IgA
antibody began to appear on the 4th day after the onset and showed 100% positivity on the 8th day. The
virus strain in the present outbreak was highly similar to the virus isolated in Hanzhong Shaanxi in
2009. We conclude that HAdV‐7 was the pathogen corresponding to the outbreak, and this is the first
report of an ARD outbreak caused by HAdV‐7 in military persons in China. Vaccine development, as
well as enhanced epidemiological and virological surveillance of HAdV infections in China should be
emphasized.

Key words China, human adenovirus type 7 (HAdV‐7), military training camp, outbreak.

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Informasi Detail

Judul Seri

Microbiol Immunol

No. Panggil

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Penerbit

: The Societies and Wiley Publishing Asia., 2013

Deskripsi Fisik

Microbiol Immunol 2013; 57: 553–560 doi: 10.1111/1348-0421.12074

Bahasa

English

ISBN/ISSN

doi: 10.1111/1348-04

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KESEHATAN

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

Lampiran Berkas

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