e-journal

Improved protective efficacy of a chimeric Staphylococcus aureus vaccine candidate iron‐regulated surface determinant B (N126–P361)‐target of RNAIII activating protein in mice

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The pathogen Staphylococcus aureus causes a wide range of serious infections, necessitating urgent
development of a vaccine against this organism. However, currently developed vaccines are relatively
ineffective because of the limited antigenic component that is contained in the vaccine formulations. To
develop an effective S. aureus candidate vaccine, overlapping PCR was used to add the truncated
immunodominant antigen iron‐regulated surface determinant B (IsdB)(N126–P361) (tIsdB) to the
N‐terminal of intact antigen target of RNAIII activating protein (TRAP) and thus construct a tIsdBTRAP
chimera. The humoral and cellular immune responses against tIsdB‐TRAP were compared with those against single or combined formulations. tIsdB‐TRAP elicited significantly stronger humoral responses in mice (P

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Ketersediaan

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Informasi Detail

Judul Seri

Microbiol Immunol

No. Panggil

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Penerbit

: The Societies and Wiley Publishing Asia., 2013

Deskripsi Fisik

Microbiol Immunol 2013; 57: 857–864 doi: 10.1111/1348-0421.12106

Bahasa

English

ISBN/ISSN

doi: 10.1111/1348-04

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KESEHATAN

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

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