e-journal

Brucella melitensis 16MDhfq attenuation confers protection against wild‐type challenge in BALB/c mice

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Brucellosis is a globally distributed zoonotic disease that causes animal and human diseases. Although
effective, the current Brucella vaccines (Rev.1 and M5‐90) have several drawbacks. The first involves
residual virulence for animals and humans and the second is the inability to differentiate natural
infection from that caused by vaccination. Therefore, Brucella melitensis 16M hfq mutant (16MDhfq) was
constructed to overcome these drawbacks. Similarly to Rev.1 and M5‐90, 16MDhfq reduces survival in
macrophages and mice and induces strong protective immunity in BALB/c mice. Moreover, these
vaccines elicit anti‐Brucella‐specific IgG1 and IgG2a subtype responses and induce secretion of gamma
interferon and interleukin‐4. The Hfq antigen also allows serological differentiation between infected
and vaccinated animals. These results show that 16MDhfq is an ideal live attenuated vaccine candidate
against virulent Brucella melitensis 16M infection. It will be further evaluated in sheep.

Key words Brucella melitensis, Hfq, live attenuated, vaccine candidate.

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Ketersediaan

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Informasi Detail

Judul Seri

Microbiol Immunol

No. Panggil

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Penerbit

: The Societies and Wiley Publishing Asia., 2013

Deskripsi Fisik

Microbiol Immunol 2013; 57: 502–510 doi: 10.1111/1348-0421.12065

Bahasa

English

ISBN/ISSN

doi: 10.1111/1348-04

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KESEHATAN

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

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