e-journal

Amyotrophic Lateral Sclerosis

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Amyotrophic lateral sclerosis is a progressive neurodegenerative syndrome characterized by loss of motor neurons. Cognitive impairment occurs in a significant proportion of those affected. Numerous theories of
pathogenesis have been advanced. The most cogent hypothesis is that genetic susceptibilities to neurodegeneration interact with environmental exposures, leading to neuronal injury, glial activation and neuronal death. Modern tools of molecular and cell biology and constructive international collaborations have provided insights into the factors that increase disease susceptibility. The important observation that genes associated with ribonucleic acid (RNA) processing are implicated in disease pathogenesis will undoubtedly influence the direction of research in the coming years. These factors, combined with improvements in clinical trial design, and an improved understanding of the limitations of translating positive findings from animal models to human subjects, are likely to lead to new and successful therapeutic options for patients in the near future.

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Ketersediaan

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Informasi Detail

Judul Seri

Encyclopedia of Life Sciences (ELS)

No. Panggil

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Penerbit

London : John Wiley & Sons, Ltd.., 2010

Deskripsi Fisik

Encyclopedia of Life Sciences (ELS), 15th February 2010

Bahasa

English

ISBN/ISSN

DOI: 10.1002/9780470

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

agus

Versi lain/terkait

Lampiran Berkas

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