e-journal

Antibiotics and the Evolution of Antibiotic Resistance

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Antibiotics were introduced for human therapy few decades ago and their utilization has produced the rapid evolution of bacterial pathogens towards resistance. Before this recent and fast evolution, antibiotics and
their resistance genes have evolved for millions of years in environmental microorganisms. Recent results suggest that, besides serving for inhibiting the growth of competitors, antibiotics might be signalling molecules in natural ecosystems and that some metabolic enzymes and signal-trafficking effluxpumpsmightrender a phenotype of resistance in the presence of high concentrations of antibiotics. Antibiotic resistance can be developed by mutation or by the acquisition of resistance determinants by means of horizontal gene transfer. Spread of resistance is achieved through the combination of different elements, from resistance genes to plasmids and bacterial clones. The release of high amounts of antibiotics and resistance genes in natural habitats is challenging the microbial populations present in these ecosystems.

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Ketersediaan

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Informasi Detail

Judul Seri

ENCYCLOPEDIA OF LIFE SCIENCES

No. Panggil

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Penerbit

London : John Wiley & Sons, Ltd.., 2009

Deskripsi Fisik

ENCYCLOPEDIA OF LIFE SCIENCES - 2009

Bahasa

English

ISBN/ISSN

DOI: 10.1002/9780470

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

15th December 2009

Subjek

KESEHATAN

Info Detail Spesifik

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Pernyataan Tanggungjawab

agus

Versi lain/terkait

Lampiran Berkas

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