e-journal

Blood–Brain Barrier

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The blood–brain barrier consists of endothelial cells lining brain capillaries. It serves to restrict and control the movement of substances between the general circulation and brain extracellular fluid. It participates in regulating the volume and composition of fluid surrounding the brain through specific transport processes, and thus contributes to homoeostasis of the central nervous system. Some of these processes may be regulated hormonally, or modulated by adjacent cells including astrocytes. The barrier function of the blood–brain barrier is due to: (1) tight junctions that restrict movementof substances between the endothelial cells, (2) specific transport proteins that determine which substances can cross the barrier transcellularly and (3) enzymes that may degrade or alter substances prior to passage. Systemically administered drugs intended to treat neurological disorders must be designed to bypass the restrictive elements of the blood–brain barrier. Pathological conditions associated with the central nervous system may alter blood–brain barrier function.

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Ketersediaan

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Informasi Detail

Judul Seri

Encyclopedia of Life Sciences (ELS)

No. Panggil

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Penerbit

London : John Wiley & Sons, Ltd.., 2012

Deskripsi Fisik

Encyclopedia of Life Sciences (ELS), 15th February 2012

Bahasa

English

ISBN/ISSN

DOI: 10.1002/9780470

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

15th August 2012

Subjek

BIOLOGI KEDOKTERAN

Info Detail Spesifik

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Pernyataan Tanggungjawab

agus

Versi lain/terkait

Lampiran Berkas

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