e-journal

The expression of selected genes linked to metabolic homeostasis in obese pansteatitis-suffering Mozambique tilapia, Oreochromis mossambicus (Peters)

---

The Oreochromis mossambicus (Peters) population inhabiting Lake Loskop, South Africa, is characterized
by a high incidence of obesity and pansteatitis. We investigated potential links between the
impaired health of Lake Loskop O. mossambicus and the endocrine system by assessing the expression of selected genes associated with the thyroid and adrenal endocrine axes as well as peroxisome proliferator-activated receptor gamma (pparg). Moreover, contaminant-induced thyroid and/or metabolic modulation in Lake Loskop water was evaluated using juvenile O. mossambicus in labora ory exposures. The expression of thyroid hormone receptor alpha (thra) and type 2 deiodinase (dio2) was higher in Lake Loskop O. mossambicus than fish from another population, suggesting a degree
of thyroid disruption. The altered gene expression may be a consequence, rather than cause of obesity.
Expression of dio2 and pparg was higher in juvenile O. mossambicus exposed to unfiltered compared to filtered lake water, and our data suggest fasting as causative factor. Micro-organism abundance can therefore be a confounding factor in studies applying molecular markers to test for thyroid modulation by environmental waters. Pansteatitis
was not a significant source of variance in the expression of any of the genes investigated,suggesting that the disease is not associated with disrupted endocrine signalling.

Keywords: endocrine disruptors, fish, Lake Loskop,obesity, pollution, thyroid

---

Ketersediaan

Tidak ada salinan data

Informasi Detail

Judul Seri

Journal of Fish Diseases

No. Panggil

-

Penerbit

: John Wiley & Sons Ltd., 2016

Deskripsi Fisik

Journal of Fish Diseases 2016, 39, 69–85

Bahasa

English

ISBN/ISSN

doi:10.1111/jfd.1232

Klasifikasi

-

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

-

Subjek

Agriculture

Info Detail Spesifik

-

Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

Lampiran Berkas

Komentar

---

Anda harus masuk sebelum memberikan komentar