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A Low Power Sub- W Chemical Gilbert Cell for ISFET Differential Reaction Monitoring

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This paper presents a low power current-mode method for monitoring differentially derived changes in pH from ion-sensitive field-effect transistor (ISFET) sensors, by adopting the Chemical Gilbert Cell. The fabricated system, with only a few transistors, achieves differential measurements and therefore
drift minimisation of continuously recorded pH signals obtained from biochemical reactions such as DNA amplification in addition to combined gain tunability using only a single current. Experimental
results are presented, demonstrating the capabilities of the front-end at a microscopic level through integration in a lab-on-chip (LoC) setup combining a microfluidic assembly, suitable for applications that require differential monitoring in small volumes, such as DNA detection where more than one gene
needs to be studied. The system was designed and fabricated in a typical 0.35 m CMOS process with the resulting topology achieving good differential pH sensitivity with a measured low power consumption of only 165 nW due to weak inversion operation. A tunable gain is demonstrated with results confirming
15.56 dB gain at 20 nA of ISFET bias current and drift reduction of up to 100 times compared to a single-ended measurement is also reported due to the differential current output, making it ideal for
robust, low-power chemical measurement.
Index Terms—Chemical Gilbert cell, drift reduction, gain tunability, ion-sensitive field-effect transistor (ISFET), lab-on-chip, low power.

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Ketersediaan

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Informasi Detail

Judul Seri

IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS

No. Panggil

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Penerbit

New York : IEEE., 2014

Deskripsi Fisik

IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS, VOL. 8, NO. 4, AUGUST 2014

Bahasa

English

ISBN/ISSN

1932-4545

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

VOL. 8, NO. 4, AUGUST 2014

Subjek

TEKNIK

Info Detail Spesifik

-

Pernyataan Tanggungjawab

Yuli/Agus

Versi lain/terkait

Lampiran Berkas

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