e-journal

Ancient DNA: the next generation – chapter and verse

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As the field of ancient DNA (aDNA) enters its third decade, it is perhaps time to reflect on the amazing
transformation that it has undergone. Early analyses of aDNA focused on mitochondrial and/or chloroplast DNA,
which were abundantly available in the cell, making retrieval and reproducibility much easier. Study of
mitochondrial DNA through time allows evolutionary relationships between species to be resolved, molecular
clocks to be calibrated, the geographical origins of samples to be revealed, and demographic histories to be
investigated. However, not until the advent of massive parallel sequencing [also know as second-generation
sequencing and next-generation sequencing (NGS)] was it possible to retrieve and study nuclear DNA on a more
routine basis. Ancient nuclear DNA can additionally be used to identify extinct phenotypes, assess the degree of
admixture, and examine selection pressures. This is a short review of what has been, and what may come, in how
aDNA has influenced NGS. Although examples from archaeology are used to illustrate the impact of NGS
technologies on the field, this approach has also been successfully applied to a range of disciplines, such as
medicine and wildlife forensics.

ADDITIONAL KEYWORDS: sequencing.

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Ketersediaan

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Informasi Detail

Judul Seri

Biological Journal of the Linnean Society

No. Panggil

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Penerbit

: The Linnean Society of London., 2016

Deskripsi Fisik

Biological Journal of the Linnean Society, 2016, 117, 150–160

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

BIOLOGI

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

Lampiran Berkas

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