e-journal

Sorghum-based alcoholic beverage, Burukutu, perturbs the redox status of the liver of male rats

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The redox status of male rat liver following 28 days consumption of Burukutu
was investigated. Twenty rats were randomized into four groups with five rats
each. Burukutu consumption at 0.78 g/kg alcohol produced no significant change
in the activities of alkaline phosphatase (ALP), alanine aminotransferase (ALT),
and aspartate aminotransferase (AST). However, 3.71 and 7.43 g/kg dosages
resulted in significant decrease in the activities of ALP, ALT and AST with corresponding
increase in serum. The activity of cytochrome P450(CYP 2E1) increased
significantly in the liver of rats following consumption of Burukutu at all doses
investigated. The activities of superoxide dismutase, catalase, glutathione peroxidase,
glutathione reductase and glucose 6-phosphate dehydrogenase decreased
significantly (P < 0.05) in rats treat with 0.78 g/kg, 3.41 and 7.43 g/kg Burukutu.
There was a significant increase in the level of glutathione disulfide (GSSG) with
reduction in the levels of glutathione reduced (GSH) and GSH:GSSG. The levels
of oxidative stress biomarkers, malondialdehyde, conjugated dienes, lipid hydroperoxides,
protein carbonyl and percentage DNA fragmentation, increased significantly
(P < 0.05). It is evident from the alterations in the activities of the
hepatocellular enzymes, antioxidant enzymes and oxidative stress biomarkers that
Burukutu mediated its toxicity through the depletion of the antioxidant enzymes.

Keywords: Burukutu, DNA fragmentation, lipid peroxidation, protein oxidation, redox status, sorghum-based beer

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Informasi Detail

Judul Seri

Food Science & Nutrition

No. Panggil

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Penerbit

New York : Wiley Periodicals, Inc.., 2014

Deskripsi Fisik

Food Science & Nutrition 2014; 2(5): 591– 596

Bahasa

English

ISBN/ISSN

doi: 10.1002/fsn3.13

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

2014; 2(5)

Subjek

GIZI DAN PANGAN

Info Detail Spesifik

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Pernyataan Tanggungjawab

agus

Versi lain/terkait

Lampiran Berkas

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