e-journal

Energy intake, metabolic homeostasis, and human health

---

2014AbstractThe energy substances (mainly carbohydrates and fats) are the basis and guarantee of life activity, especially the oxidative phosphorylation forenergy supply. However, excessive absorption and accumulation of these substances can lead to metabolic diseases such as obesity, hyperlipidemia,diabetes, and cancers. A large amount of studies demonstrate that G protein-coupled receptors (GPCRs) play a key role in identification andabsorption of energy substances, and the signaling network of nerves, immune, and endocrine regulates their storage and utilization. The gas-trointestinal mucus layer not only identifies these substances through identification in diet components but also transfers immune, metabolic, andendocrine signals of hormones, cytokines, and chemokines by promoting interactions between receptors and ligands. These signaling moleculesare transferred to corresponding organs, tissues, and cells by the circulatory system, and cell activity is regulated by amplifying of cell signals thatconstitute the wireless communication network among cells in the body. Absorption, accumulation, and utilization of energy substances in the bodyobey the law of energy conservation. Energy is stored in the form of fat, and meets the demand of body via two coupled mechanisms: catabolismand oxidative phosphorylation. Under normal physiological conditions, fat consumption involves ketone body metabolism through the circulatorysystem and glucose consumption requires blood lactic acid cycle. Accumulation of excessive energy leads to the abnormal activation of mammaliantarget of rapamycin (mTOR), thus promoting the excretion of glucose or glycogen in the form of blood glucose and urine glucose. Alternatively,the body cancels the intercellular contact inhibition and promotes cell proliferation to induce carcinogenesis, which can induce the consumption oflarge amounts of glucose. Intercellular communication is performed by signaling molecules via sensing, absorption, accumulation, and utilizationof energy substances, and anabolism and catabolism are controlled by the central metabolic pathway. Therefore, slower catabolism will resultin longer life expectancy, whereas faster catabolism results in shorter life expectancy. Energy substances in diet influence the balance betweenenergy and metabolism in the body through the sensing function of the gastrointestinal system at two levels: cellular communication network andmetabolic network. The present review of studies aims to strengthen our knowledge on cellular communication and metabolic networks to offer adietary guidance on the metabolism and communication role of various foods.

Keywords: Energy substance; Metabolism balance; Metabolic syndrome; Wireless intercellular communication network; Metabolic network; Human health1

---

Ketersediaan

Tidak ada salinan data

Informasi Detail

Judul Seri

Food Science and Human Wellness 3 (2014) 89–103

No. Panggil

-

Penerbit

: Oxford University Press on behalf of the Agricultural and Applied Economics Association.., 2014

Deskripsi Fisik

Food Science and Human Wellness 3 (2014) 89–103

Bahasa

English

ISBN/ISSN

-

Klasifikasi

-

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

-

Subjek

Food And Health

Info Detail Spesifik

-

Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

Lampiran Berkas

Komentar

---

Anda harus masuk sebelum memberikan komentar